Abstract:
Objective: It is known that genetic variations in the mechanism of taste perception play an essential role in food intake. In this study, we investigated the SNP rs35874116 polymorphism in the sweet taste receptor (TAS1R2) gene and nutrient intakes of adults. Methods: The study conducted with 95 volunteers. Food consumption records of participants obtained by 24-h recall method, and analyzed by Computer-Aided Nutrition Software, Nutrition Information Systems 8.1 Package Software (BeBiS). Venous blood samples of the participants were collected to determine genotype distribution, and genotype distributions were determined using the Kompetitive Allele-Specific PCR (KASP) method. Results: The genotype examination of participants revealed that the percentage of individuals with GA, AA, and GG genotypes were 67.3%, 26.3%, and 6.3% respectively. Daily total carbohydrate and sucrose intakes were found as the highest in individuals with GG genotype (145.55 +/- 56.69 g and 28.66 +/- 26 g, respectively), but without statistical difference. Conclusion: According to our knowledge the study is the first to examine TAS1R2 polymorphism and nutrient intake in the Turkish population. We did not find any difference between TAS1R2 (rs35874116) polymorphism and nutrient intake; however, the study may serve as a preliminary result. Studies with a wider sample may help to enhance our understanding of the TAS1R2 and nutrient intake.
